Dr. Darren Costain
Dr. Darren J. Costain was born and raised in the small Maritime town of Riverview, New Brunswick. He attended Dalhousie University in Halifax, Nova Scotia, where he obtained a Bachelor of Science degree in Microbiology & Immunology (with honours), Master of Science degree (Pathology), Bachelor of Science in Medicine, and Doctorate of Medicine (with distinction). He subsequently completed his residency training in Orthopaedic Surgery in Halifax. As an orthopedic surgery resident, he was successful in obtaining research funding for a basic science project in cancer immunotherapy. He was also awarded the Excellence in Teaching Award for the Department of Surgery as a senior resident.
In 2007, Dr. Costain travelled to Brisbane, Australia, to complete subspecialty fellowship training in complex hip and knee arthroplasty. There, he worked under Dr. Ross Crawford to learn proper cementation techniques, revision arthroplasty expertise, and specifically impaction allograft reconstruction techniques to address complex bone deficits at the time of joint replacement surgery. He moved to Sault Ste. Marie in 2008 to pursue a career in total knee and total hip reconstruction.
Dr. Costain’s research interests include the use of tranexamic acid in hip fractures (peer-reviewed grant funding of $50 000), the use of bone graft with orthopedic surgery, and computer-assisted surgery. Together with the Orthopaedics Division at the Sault Area Hospital, Dr. Costain is attempting to establish a niche of excellence in clinical research. Dr. Costain values teaching and enjoys exposing students at various levels of training to orthopedic surgery.
Costain, DJ, Crawford RW. 2009. Fresh-frozen vs. irradiated allograft bone in orthopedic reconstructive surgery. Injury 40(12):1260-4
Costain, DJ, Oxner, W, Alexander, D, and Gross, M. 2007. Dalhousie University Spine Database: Prospective analysis of disability, pain, depression, and patient-perceived influence of referral delay on outcome. Canadian Orthopaedic Association Annual Meeting (Abstract)
Costain, DJ, Gross, M, Dunbar, M, and Lee, TDG. 2007. Osteolysis in cancer: A role for the genetic manipulation of RANK expression. Canadian Orthopaedic Association Annual Meeting (Abstract)
Costain, DJ, Guha, AK, Liwski, RS, and Lee, TDG. 2001. Murine hypodense eosinophils induce tumor cell apoptosis by a granzyme B-dependent mechanism. Cancer Immunol. Immunother. 50(6):293-99
Costain, DJ, Guha, AK, and Lee, TDG. 1998. Granzyme-B-mediated apoptosis: A novel tumoricidal mechanism of hypodense eosinophils. Clin. Invest. Med. 21(4) (Abstract)
Costain, DJ. 1998. Eosinophils in cancer: Mechanisms and machinery for cytotoxicity. Dal. Med. J. 26(1):14-24
Costain, DJ, Guha, AK, and Lee, TDG. 1998. Comparison of hypodense and normodense eosinophil anti-tumour cytotoxic activity. 12th Spring Meeting of the Canadian Society for Immunology. (Abstract) 4.8
Costain, DJ, Kennedy, R, Ciona, C, McAlister, VC, and Lee, TDG. 1997. Prevention of post-surgical adhesions with N,O-carboxymethyl chitosan (NOCC): Examination of the most efficacious preparation and the effect of NOCC on post-surgical healing. Surgery 121:314-9
Kennedy, R, Costain, DJ, McAlister, VC, and Lee, TDG. 1996. Prevention of experimental post-operative adhesions by N,O- carboxymethyl chitosan. Surgery 120:866-70